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The purity of rh CD74 was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
The purity of rh CD74 was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.

CD74 Recombinant Protein

CATALOG NUMBER: 96-110

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Gln 73 - Met 232
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
19.3 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized human CD74 at 5μg/ml (100μl/well) can bind biotinylated human CTSL1 with a linear range of 3. 2 - 500 ng/mL.
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
CD74
Additional Names:
CD74, DHLAG, HLADG, II, Ia-GAMMA, p33, CLIP, INVG34
Protein Accession Number:
NP_004346.1
Ncbi Gene Id Number:
972
Background:
Cluster of Differentiation 74 (CD74) is also known as HLA class II histocompatibility antigen gamma chain (HLADG), DHLAG, Ia-GAMMA, invariant chain (Abbreviated Ii). CD74 / HLADG is a polypeptide involved in the formation and transport of MHC class II protein. The cell surface form of the invariant chain is known as CD74. CD74 is upregulated in several cancers and is also expressed by non-immune cells during inflammation. CD74 plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha / beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal / lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. CD74 / DHLAG also serves as cell surface receptor for the cytokine MIF.
Background Reference 1:
Cresswell P., 1994, Annu. Rev. Immunol. 12: 259–93.
Background Reference 2:
Charest A., et al., 2003, Genes Chromosomes Cancer 37:58-71.
Background Reference 3:
Leng L., et al., 2003, J. Exp. Med. 197:1467-1476.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-110

List Size:
0.1 mg

List Price:

$515.00

Datasheet
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