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CD80 Antibody [16-10A1]

CATALOG NUMBER: 76-040

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays, IF, IHC, IP
Host Species:
Hamster
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Hamster
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays, IF, IHC, IP
Specificity:
The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR).
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Armenian Hamster IgG
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
Cd80
Additional Names:
B71, Ly53, TSA1, Cd28l, Ly-53, MIC17, Cd80
Ncbi Gene Id Number:
12519
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The 16-10A1 antibody reacts with mouse CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
Background Reference 1:
Razi-Wolf, Z., Freeman, G. J., Galvin, F., Benacerraf, B., Nadler, L., Reiser, H. (1992). Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells.Proceedings of the National Academy of Sciences,89(9), 4210-4214.
Background Reference 2:
Hathcock, K. S., Laszlo, G., Pucillo, C., Linsley, P., Hodes, R. J. (1994). Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.The Journal of experimental medicine,180(2), 631-640.
Background Reference 3:
Harlan, D. M., Hengartner, H., Huang, M. L., Kang, Y. H., Abe, R., Moreadith, R. W., ... Freeman, G. J. (1994). Mice expressing both B7-1 and viral glycoprotein on pancreatic beta cells along with glycoprotein-specific transgenic T cells develop diabetes due to a breakdown of T-lymphocyte unresponsiveness.Proceedings of the National Academy of Sciences,91(8), 3137-3141.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-040

List Size:
0.1 mg

List Price:

$253.00

Datasheet
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