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CD80 Antibody [2D10.4]

CATALOG NUMBER: 76-035

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays
Specificity:
The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR).
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality:
Monoclonal
Isotype:
Mouse IgG1, kappa
Physical State:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C . Do not freeze.
Ncbi Official Symbol:
CD80
Additional Names:
B7, BB1, B7-1, B7.1, LAB7, CD28LG, CD28LG1, CD80
Ncbi Gene Id Number:
941
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
Background Reference 1:
Leucocyte Typing VI: White Cell Differentiation Antigens: Proceedings of the Sixth International Workshop and Conference Held in Kobe, Japan, 10-14 November 1996. Garland Pub., 1998.
Background Reference 2:
Cognasse, F., HamzehCognasse, H., Lafarge, S., Chavarin, P., Pozzetto, B., Richard, Y., Garraud, O. (2008). Identification of two subpopulations of purified human blood B cells, CD27 CD23+ and CD27high CD80+, that strongly express cell surface Tolllike receptor 9 and secrete high levels of interleukin6.Immunology,125(3), 430-437.
Background Reference 3:
Bashuda, H., Kimikawa, M., Seino, K., Kato, Y., Ono, F., Shimizu, A., ... Okumura, K. (2005). Renal allograft rejection is prevented by adoptive transfer of anergic T cells in nonhuman primates.Journal of Clinical Investigation,115(7), 1896-1902.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-035

List Size:
0.5 mg

List Price:

$577.00

Datasheet
Shipping Info

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