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CD86 Antibody [GL-1 (GL1)] (PE)

CATALOG NUMBER: 76-603

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
PE
Specifications
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
PE
Tested Applications:
Flow
Specificity:
The GL-1 monoclonal antibody reacts specifically with the mouse B7-2 (also known as CD86), a costimulatory molecule expressed by B and T lymphocytes, macrophages (thioglycollate-induced from peritoneum), astrocytes and dendritic cells.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Rat IgG2a, kappa
Physical State:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
Cd86
Additional Names:
B7, B70, MB7, B7-2, B7.2, CLS1, Ly58, ETC-1, Ly-58, MB7-2, Cd28l2, TS/A-2, Cd86
Ncbi Gene Id Number:
12524
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The GL-1 monoclonal antibody reacts specifically with the mouse B7-2 (also known as CD86), a costimulatory molecule expressed by B and T lymphocytes, macrophages (thioglycollate-induced from peritoneum), astrocytes and dendritic cells. The memory CD4+ T lymphocytes express CD86 (as mRNA and protein). CD86, and the B7-1 (CD 80) molecule, are ligands for CD152 and CD28, and influence the costimulatory interactions between lymphocytes B and T. B7-2 is also involved in the mouse natural killer cell-mediated cytotoxicity. The GL-1 antibody blocks the mixed lymphocyte reaction (MLR) and inhibits the T-cells stimulation by antigen-presenting cells. Mixtures of anti-B7-1 antibody and GL-1 were reported to inhibit the interaction between CD125 and its ligand with the in vivo priming of cytotoxic T lymphocytes.
Background Reference 1:
Hathcock, K. S., Laszlo, G., Dickler, H. B., Bradshaw, J., Linsley, P., Hodes, R. J. (1993). Identification of an alternative CTLA-4 ligand costimulatory for T cell activation.Science,262(5135), 905-907.
Background Reference 2:
Inaba, K., Witmer-Pack, M., Inaba, M., Hathcock, K. S., Sakuta, H., Azuma, M., ... Steinman, R. M. (1994). The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro.The Journal of experimental medicine,180(5), 1849-1860.
Background Reference 3:
Hathcock, K. S., Laszlo, G., Pucillo, C., Linsley, P., Hodes, R. J. (1994). Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.The Journal of experimental medicine,180(2), 631-640.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-603

List Size:
0.025 mg

List Price:

$217.00

Datasheet
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