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CD8a Antibody [2.43] (Violet-450)

CATALOG NUMBER: 76-648

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
Violet-450
Specifications
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
Violet-450
Tested Applications:
Flow
Specificity:
The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Rat IgG2b
Physical State:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
Cd8a
Additional Names:
Ly-2, Ly-B, Ly-35, Lyt-2, BB154331, Cd8a
Ncbi Gene Id Number:
12525
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen. CD8a (the alpha chains) form heterodimers with CD8b (the beta chains) or homodimers (alpha-alpha), which occur as receptors on the surface of the majority of thymocytes. A subpopulation of mature T lymphocytes expresses the CD8 alpha beta (alpha beta TCR T cells), and a subpopulation of intestinal intraepithelial lymphocytes and dendritic cells express CD8a without CD8b. CD8 interacts with the mouse major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells. BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Background Reference 1:
Salem, M. L., Hossain, M. S. (2000). In vivo acute depletion of CD8+ T cells before murine cytomegalovirus infection upregulated innate antiviral activity of natural killer cells. International journal of immunopharmacology,22(9), 707-718.
Background Reference 2:
Kruisbeek, A. M. (1991). In Vivo Depletion of CD4 and CD8 Specific T Cells.Current protocols in immunology, 4-1.
Background Reference 3:
Davies, A., Kalb, S., Liang, B., Aldrich, C. J., Lemonnier, F. A., Jiang, H., ... Soloski, M. J. (2003). A peptide from heat shock protein 60 is the dominant peptide bound to Qa-1 in the absence of the MHC class Ia leader sequence peptide Qdm.The Journal of Immunology,170(10), 5027-5033.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-648

List Size:
0.025 mg

List Price:

$249.00

Datasheet
Shipping Info

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