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Paraffin embedded chicken spleen tissue was stained with Mouse Anti-Chicken CD8?-UNLB (Cat. No. 99-212; right) followed by Anti-Mouse IgG-HRP and DAB.
Paraffin embedded low pathogenic avian influenza virus infected lung section was stained with Mouse Anti-Chicken CD8?-UNLB (Cat. No. 99-212) followed by a secondary antibody, DAB, and haematoxylin.Image from Rebel JM, Peeters B, Fijten H, Post J, Cornelissen J, Vervelde L. Highly pathogenic or low pathogenic avian influenza virus subtype H7N1 infection in chicken lungs: small differences in general acute responses. Vet Res. 2011;42:10. Figure 4(a)
Paraffin embedded high pathogenic avian influenza virus infected lung section was stained with Mouse Anti-Chicken CD8?-UNLB (Cat. No. 99-212) followed by a secondary antibody, DAB, and haematoxylin.Image from Rebel JM, Peeters B, Fijten H, Post J, Cornelissen J, Vervelde L. Highly pathogenic or low pathogenic avian influenza virus subtype H7N1 infection in chicken lungs: small differences in general acute responses. Vet Res. 2011;42:10. Figure 4(c)
Frozen chicken ovarian tumor section was stained with Mouse Anti-Chicken CD8?-UNLB (Cat. No. 99-212) followed by an HRP conjugated secondary antibody, DAB, and hematoxylin.Image from Bradaric MJ, Barua A, Penumatsa K, Yi Y, Edassery SL, Sharma S, et al. Sphingosine-1 phosphate receptor (S1p1), a critical receptor controlling human lymphocyte trafficking, is expressed in hen and human ovaries and ovarian tumors. J Ovarian Res. 2011;4:4. Figure 7(d)
Paraffin embedded chicken spleen tissue was stained with Mouse Anti-Chicken CD8?-UNLB (Cat. No. 99-212; right) followed by Anti-Mouse IgG-HRP and DAB.

CD8a Antibody [CT-8]

CATALOG NUMBER: 99-212

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Mouse
Species Reactivity:
Chicken, Guinea Fowl, Pigeon, Turkey
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Chicken, Guinea Fowl, Pigeon, Turkey
Immunogen:
Chicken thymocytes and Ig-negative blood leukocytes
Conjugate:
Unconjugated
Tested Applications:
Flow
Application Note:
CD8a Antibody [CT-8] for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, and blocking assays.
Specificity:
CD8alpha
Clonality:
Monoclonal
Isotype:
IgG1
physical-state:
Liquid
Buffer:
Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added
Concentration:
0.5 mg/mL
Storage Conditions:
Store vial at 2-8°C
Ncbi Official Symbol:
CD8A
Ncbi Gene Id Number:
403158
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
In the chicken, the CD8 molecule is present in two forms - (i) a homodimer of two alpha chains and (ii) a heterodimer of an alpha chain and a beta chain. While the vast majority of CD8+ cells in the thymus, spleen, and blood of adult chickens express both CD8alpha- and CD8beta-chains, a relatively large proportion of the CD8+ TCRgammadelta cells in the spleens of embryos and young chicks express only the alpha-chain of CD8. Among intestinal epithelial lymphocytes, the major CD8+ T cell populations present in mice are conserved but there is a population of TCRgammadelta CD8alphabeta cells in the chicken that is not found in rodents. Chicken CD8 is expressed on approximately 80% of thymocytes, 15% of blood mononuclear cells, and 50% of spleen cells but less than 1% of cells in the bursa and bone marrow. The monoclonal antibody CT-8 recognizes the CD8alpha chain and has been shown to react to a polymorphic determinant in turkey.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

99-212

List Size:
0.5 mg

List Price:

$463.00

Datasheet
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