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CD90.2 Antibody [30-H12] (Violet-450)

CATALOG NUMBER: 76-071

Clonality:
Monoclonal
Tested Applications:
Flow
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
Violet-450
Specifications
Host Species:
Rat
Species Reactivity:
Mouse
Conjugate:
Violet-450
Tested Applications:
Flow
Specificity:
The 30-H12 monoclonal antibody specifically binds to MouseCD90.2, an alloantigen known as Thy-1.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Clonality:
Monoclonal
Isotype:
Rat IgG2b
Physical State:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Ncbi Official Symbol:
Thy1
Additional Names:
T25, CD90, Thy-1, Thy1.1, Thy1.2, Thy-1.2, Thy1
Ncbi Gene Id Number:
21838
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The 30-H12 monoclonal antibody specifically binds to MouseCD90.2, an alloantigen known as Thy-1.2, expressed on thymocytes, mature T cells, epithelial cells, neurons, hematopoietic stem cells, and fibroblasts. CD90 is a membrane glycoprotein that regulates the adhesion and signal transduction in T lymphocytes, and the adhesion of thymocytes to thymic stroma. The interaction between 30-H12 and the antibody to the CD3/TCR complex upregulates thymocytes signal transduction and apoptosis and downregulates mature T cell proliferation. The 30-H12 antibody seems to be unable to cross-link with CD90.1.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Background Reference 1:
Ledbetter, J. A., Herzenberg, L. A. (1979). Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*.Immunological reviews,47(1), 63-90.
Background Reference 2:
Radrizzani, M., Carminatti, H., Pivetta, O. H., Vargas, V. P. (1995). Developmental regulation of Thy 1.2 rate of synthesis in the mouse cerebellum.Journal of neuroscience research,42(2), 220-227.
Background Reference 3:
Seaman, W. E., Wofsy, D., Greenspan, J. S., Ledbetter, J. A. (1983). Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease.The Journal of Immunology,130(4), 1713-1718.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-071

List Size:
0.025 mg

List Price:

$217.00

Datasheet
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