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CD95 Antibody [EOS9.1]

CATALOG NUMBER: 76-567

Clonality:
Monoclonal
Tested Applications:
Flow, Functional Assays
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Tested Applications:
Flow, Functional Assays
Specificity:
The EOS9.1 monoclonal antibody specifically reacts with human CD95, a 45 kDA type I membrane molecule. CD95 is a member of the tumor necrosis factor receptor (TNF-R) family and is involved in the mechanisms that lead to cellular apoptosis.
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality:
Monoclonal
Isotype:
Mouse IgM, kappa
physical-state:
Liquid
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Storage Conditions:
The product should be stored undiluted at 4°C . Do not freeze.
Ncbi Official Symbol:
FAS
Additional Names:
APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6, FAS
Ncbi Gene Id Number:
355
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The EOS9.1 monoclonal antibody specifically reacts with human CD95, a 45 kDA type I membrane molecule. CD95 is a member of the tumor necrosis factor receptor (TNF-R) family and is involved in the mechanisms that lead to cellular apoptosis. It is expressed on fibroblasts, monocytes, lymphocytes, and neutrophils. CD95 induces apoptosis after binding with CD178 or Fas ligand and the EOS9.1 antibody is reported to be used for inducing apoptosis in Fas-positive cells.
Background Reference 1:
Deaglio, S., Zubiaur, M., Gregorini, A., Bottarel, F., Ausiello, C. M., Dianzani, U., ... Malavasi, F. (2002). Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells.Blood,99(7), 2490-2498.
Background Reference 2:
Peruzzi, G., Femnou, L., Gil-Krzewska, A., Borrego, F., Weck, J., Krzewski, K., Coligan, J. E. (2013). Membrane-type 6 matrix metalloproteinase regulates the activation-induced downmodulation of CD16 in human primary NK cells.The Journal of Immunology,191(4), 1883-1894.
Background Reference 3:
Wirthmueller, U., Kurosaki, T., Murakami, M. S., Ravetch, J. V. (1992). Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain.The Journal of experimental medicine,175(5), 1381-1390.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

76-567

List Size:
0.05 mg

List Price:

$249.00

Datasheet
Shipping Info

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