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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
Western blot analysis in mouse stomach tissue lysates (35ug/lane).
Western blot analysis in NCI-H460 cell line lysates (35ug/lane).

CDC42EP2 Antibody

CATALOG NUMBER: 58-973

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This CDC42EP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-160 amino acids from the C-terminal region of human CDC42EP2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
22 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CDC42EP2
Additional Names:
Cdc42 effector protein 2, Binder of Rho GTPases 1, CDC42EP2, BORG1, CEP2
Protein Accession Number:
O14613
Ncbi Gene Id Number:
10435
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
CDC42, a small Rho GTPase, regulates the formation ofF-actin-containing structures through its interaction with thedownstream effector proteins. The protein encoded by this gene is amember of the Borg family of CDC42 effector proteins. Borg familyproteins contain a CRIB (Cdc42/Rac interactive-binding) domain.They bind to, and negatively regulate the function of, CDC42.Coexpression of this protein with dominant negative mutant CDC42protein in fibroblast was found to induce pseudopodia formation,which suggested a role of this protein in actin filament assemblyand cell shape control.
Background Reference 1:
Xue, Y., et al. Int. J. Cancer 118(12):2965-2972(2006)
Background Reference 2:
Joberty, G., et al. Nat. Cell Biol. 3(10):861-866(2001)
Background Reference 3:
Hirsch, D.S., et al. J. Biol. Chem. 276(2):875-883(2001)
Background Reference 4:
Joberty, G., et al. Mol. Cell. Biol. 19(10):6585-6597(1999)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-973

List Size:
400 ul

List Price:

$495.00

Datasheet
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