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Western blot analysis of CDO1 in rat liver tissue lysate with CDO1 antibody at (A) 1 and (B) 2 μg/ml.
Western blot analysis of CDO1 in rat liver tissue lysate with CDO1 antibody at (A) 1 and (B) 2 μg/ml.
Trial Size

CDO1 Antibody

CATALOG NUMBER: 8137

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (84%)
Immunogen:
CDO1 antibody was raised against a 19 amino acid peptide near the amino terminus of human CDO1.
The immunogen is located within amino acids 30 - 80 of CDO1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
CDO1 antibody can be used for detection of CDO1 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Specificity:
CDO1 antibody is human, mouse and rat reactive.
Positive Control 1:
Cat. No. 1464 - Rat Liver Tissue Lysate
Predicted Molecular Weight:
Predicted: 22 kDa
Observed: 24 kDa
Purification:
CDO1 antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
CDO1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
CDO1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
CDO1
Additional Names:
Cysteine dioxygenase type I, CDO, CDO-I, Cysteine dioxygenase type 1
Protein Accession Number:
NP_001792
Protein Gi Number:
56786147
Ncbi Gene Id Number:
1036
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
CDO1 (cysteine dioxygenase, type I) belongs to the cysteine dioxygenase family and is involved in organosulfur biosynthesis (1). CDO1 functions as a dioxygenase that uses iron and zinc as cofactors to catalyze the conversion of L-cysteine and oxygen to 3-sulfinoalanine (1,2). CDO1 exists as a monomer and is expressed at high levels in liver and placenta and at lower levels in brain, pancreas and heart (1). CDO1 is involved in pyruvate-, sulfate- and taurine-related metabolic pathways and is a crucial regulator of cysteine concentrations within the cell (3,4).
Background Reference 1:
McCann KP, Akbari MT, Williams AC, et al. Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA. Biochim. Biophys. Acta 1994; 1209:107-10.
Background Reference 2:
Ye S, Wu X, Wei L, et al. An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor. J. Biol. Chem. 2007; 282:3391-402.
Background Reference 3:
Booken N, Gratchev A, Utikal J, et al. Sezary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3. Leukemia 2008; 22:393-9.
Background Reference 4:
Wrangle J, Machida EO, Danilova L, et al. Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer. Clin. Cancer Res. 2014; 20:1856-64.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

8137

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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