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Western blot analysis of lysate from NCI-H1299 cell line, using CFL2 Antibody at 1:1000 at each lane.
CFL2 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human rectum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis of lysate from NCI-H1299 cell line, using CFL2 Antibody at 1:1000 at each lane.

CFL2 Antibody

CATALOG NUMBER: 57-488

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig
Immunogen:
This CFL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the N-terminal region of human CFL2.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
19 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CFL2
Additional Names:
Cofilin-2, Cofilin, muscle isoform, CFL2
Protein Accession Number:
Q9Y281
Protein Gi Number:
6831517
Ncbi Gene Id Number:
1073
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
Background Reference 1:
Vogel, S., et al. J. Biol. Chem. 285(44):33756-33763(2010) Borensztajn, K., et al. Thromb. Res. 125 (6), E323-E328 (2010)Papalouka, V., et al. Mol. Cell. Biol. 29(22):6046-6058(2009) Wu, Y., et al. Retrovirology 5, 95 (2008)Agrawal, P.B., et al. Am. J. Hum. Genet. 80(1):162-167(2007)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-488

List Size:
400 ul

List Price:

$495.00

Datasheet
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