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Western blot analysis in 293 cell line lysates (35ug/lane).
Western blot analysis in 293 cell line lysates (35ug/lane).

CHM Antibody

CATALOG NUMBER: 60-861

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This CHM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-320 amino acids from the Central region of human CHM.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
73 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CHM
Additional Names:
Rab proteins geranylgeranyltransferase component A 1, Choroideremia protein, Rab escort protein 1, REP-1, TCD protein, CHM, REP1, TCD
Protein Accession Number:
P24386
Protein Gi Number:
21431807
Ncbi Gene Id Number:
1121
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes component A of the RAB geranylgeranyltransferase holoenzyme. In the dimeric holoenzyme, this subunitbinds unprenylated Rab GTPases and then presents them to thecatalytic Rab GGTase subunit for the geranylgeranyl transferreaction. Rab GTPases need to be geranylgeranyled on either one ortwo cysteine residues in their C-terminus to localize to thecorrect intracellular membrane. Mutations in this gene are a causeof choroideremia; also known as tapetochoroidal dystrophy (TCD).This X-linked disease is characterized by progressive dystrophy ofthe choroid, retinal pigment epithelium and retina. Alternativesplicing results in multiple transcript variants encoding differentisoforms.
Background Reference 1:
Perez-Cano, H.J., et al. Am. J. Med. Genet.149A (10), 2134-2140 (2009) :
Background Reference 2:
Renner, A.B., et al. Arch. Ophthalmol. 127(7):907-912(2009)
Background Reference 3:
Sergeev, Y.V., et al. Mutat. Res. 665 (1-2), 44-50 (2009) :
Background Reference 4:
MacDonald, I.M., et al. Surv Ophthalmol 54(3):401-407(2009)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-861

List Size:
400 ul

List Price:

$495.00

Datasheet
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