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Western blot analysis in Jurkat cell line lysates (35ug/lane).
Western blot analysis in Jurkat cell line lysates (35ug/lane).

CHRNA2 Antibody

CATALOG NUMBER: 56-130

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This CHRNA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-69 amino acids from the N-terminal region of human CHRNA2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
60 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CHRNA2
Additional Names:
Neuronal acetylcholine receptor subunit alpha-2, CHRNA2
Protein Accession Number:
Q15822
Protein Gi Number:
308153405
Ncbi Gene Id Number:
1135
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Nicotinic acetylcholine receptors (nAChRs) areligand-gated ion channels formed by a pentameric arrangement ofalpha and beta subunits to create distinct muscle and neuronalreceptors. Neuronal receptors are found throughout the peripheraland central nervous system where they are involved in fast synaptictransmission. This gene encodes an alpha subunit that is widelyexpressed in the brain. The proposed structure for nAChR subunitsis a conserved N-terminal extracellular domain followed by threeconserved transmembrane domains, a variable cytoplasmic loop, afourth conserved transmembrane domain, and a short C-terminalextracellular region. Mutations in this gene cause autosomaldominant nocturnal frontal lobe epilepsy type 4. Single nucleotidepolymorphisms (SNPs) in this gene have been associated withnicotine dependence.
Background Reference 1:
Saccone, N.L., et al. Genes Brain Behav. 9(7):741-750(2010)
Background Reference 2:
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Background Reference 3:
Rigbi, A., et al. Pharmacogenomics J. (2010) In press :
Background Reference 4:
Hoda, J.C., et al. FEBS Lett. 583(10):1599-1604(2009)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-130

List Size:
400 ul

List Price:

$495.00

Datasheet
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