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Western blot analysis in A549 cell line lysates (35ug/lane).
Western blot analysis in A549 cell line lysates (35ug/lane).

CLCF1 Antibody

CATALOG NUMBER: 60-119

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This CLCF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of human CLCF1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
25 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CLCF1
Additional Names:
Cardiotrophin-like cytokine factor 1, B-cell-stimulating factor 3, BSF-3, Novel neurotrophin-1, NNT-1, CLCF1, BSF3, CLC, NNT1
Protein Accession Number:
Q9UBD9
Protein Gi Number:
56404673
Ncbi Gene Id Number:
23529
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene is a member of the glycoprotein (gp)130 cytokinefamily and encodes cardiotrophin-like cytokine factor 1 (CLCF1).CLCF1 forms a heterodimer complex with cytokine receptor-likefactor 1 (CRLF1). This dimer competes with ciliary neurotrophicfactor (CNTF) for binding to the ciliary neurotrophic factorreceptor (CNTFR) complex, and activates the Jak-STAT signalingcascade. CLCF1 can be actively secreted from cells by forming acomplex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is apotent neurotrophic factor, B-cell stimulatory agent andneuroendocrine modulator of pituitary corticotroph function.Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2).This syndrome is characterized by a profuse sweating after exposureto cold as well as congenital physical abnormalities of the headand spine. Alternative splicing results in multiple transcriptvariants encoding distinct isoforms.
Background Reference 1:
Rousseau, F., et al. J. Biol. Chem. 283(44):30341-30350(2008)
Background Reference 2:
Dagoneau, N., et al. Am. J. Hum. Genet. 80(5):966-970(2007)
Background Reference 3:
Rousseau, F., et al. Proc. Natl. Acad. Sci. U.S.A. 103(26):10068-10073(2006)
Background Reference 4:
Perret, D., et al. J. Biol. Chem. 279(42):43961-43970(2004)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-119

List Size:
400 ul

List Price:

$495.00

Datasheet
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