Clevudine

CATALOG NUMBER: 11-076

Specifications

Predicted Molecular Weight:

260.2

Formula:

C10H13FN2O5

Cas:

163252-36-6

Solubility:

Soluble in water (30mg/ml) or DMSO (20mg/ml).

Inchi Key:

GBBJCSTXCAQSSJ-XQXXSGGOSA-N

Smiles:

O[C@H]1[C@H](CO)O[C@]([H])(N2C=C(C)C(NC2=O)=O)[C@@H]1F

Identity:

Determined by 1H-NMR.

Advanced Validation

Properties

Purity:

greater than or equal to 98% (HPLC)

physical-state:

Lyophilized

Storage Conditions:

Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

Additional Info

Additional Names:

Levovir; L-FMAU; 2'-Fluoro-5-methyl-β-L-arabinofuranosyl-uracil

Background

Background:

Clevudine is a synthetic pyrimidine nucleoside analog antiviral agent with activity against hepatitis B virus (HBV) and Epstein-Barr virus (EBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase and reverse transcriptase, consequently blocking the viral replication. It also blocks the DNA supply of the virus into the nucleus, reducing the amount of cccDNA by 20-100 times.Potentially useful for the treatment of the SARS-CoV-2 (COVID-19) infection, acting as a potent inhibitor of the RdRp protein.

Citations

Set Contents

Disclaimer

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:

This product is for research use only.

CATALOG NUMBER:

11-076

List Size:

50 mg

List Price:

$270.00

Datasheet

Shipping Info

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$35 Dry Ice Shipment fee may be required on some items.

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