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Western blot analysis of Clusterin in human brain tissue lysate with Clusterin body at (A) 0.5 and (B) 1 μg/mL.
Immunohistochemistry of Clusterin in human brain tissue with Clusterin antibody at 5 μg/mL.
Immunofluorescence of Clusterin in human brain tissue with Clusterin antibody at 20 μg/ml.<br><br>Red: Clusterin Antibody (3856) <br> Blue: DAPI staining
Immunohistochemistry of Clusterin in human brain tissue with Clusterin antibody at 10 μg/mL.
Immunohistochemistry of Clusterin in mouse brain tissue with Clusterin Antibody at 5 μg/mL.
Immunofluorescence of Clusterin in mouse brain tissue with Clusterin Antibody at 20 μg/mL.<br><br>Green: Clusterin Antibody (3856) <br>Red: Phylloidin staining<br>Blue: DAPI staining
Western blot analysis of Clusterin in human brain tissue lysate with Clusterin body at (A) 0.5 and (B) 1 μg/mL.
Trial Size

Clusterin Antibody

CATALOG NUMBER: 3856

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
Clusterin antibody was raised recombinant human Clusterin isoform 1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
Clusterin antibody can be used for the detection of Clusterin by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human and mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1303 - Human Brain Tissue Lysate
Positive Control 2:
Cat. No. 10-301 - Human Brain Tissue Slide
Purification:
Clusterin Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Clusterin Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Clusterin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CLU
Additional Names:
Clusterin Antibody: CLI, AAG4, APOJ, CLU1, CLU2, KUB1, SGP2, APO-J, SGP-2, SP-40, TRPM2, TRPM-2, NA1/NA2, CLI, Clusterin, Aging-associated gene 4 protein, Apo-J
Protein Accession Number:
NP_001822
Protein Gi Number:
42716297
Ncbi Gene Id Number:
1191
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Clusterin Antibody: Clusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer's b-amyloid peptide. Clusterin expression is increased in Alzheimer's disease brain tissue and clusterin-immunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites and it has been suggested that clusterin facilitates the conversion of diffuse b-amyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression. Clusterin exists in at least two distinct isoforms.
Background Reference 1:
Calero M, Rostagno A, Frangione B, et al. Clusterin and Alzheimer's disease. Subcell. Biochem. 2005; 38:273-98.
Background Reference 2:
Martin-Rehrmann MD, Hoe HS, Capuani EM, et al. Association of apolipoprotein J-positive β-amyloid plaques with dystrophic neurites in Alzheimer's disease brain. Neurotox. Res. 2005; 7:231-42.
Background Reference 3:
Trougakos IP and Gonos ES. Clusterin/Apolipoprotein J in human aging and cancer. Int. J. Biochem. Cell Biol. 2002; 34:1430-48.
Background Reference 4:
Martinon F and Tschopp J. NLRs join TLRs as innate sensors of pathogens. TRENDS Imm. 2005; 26:447-54.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

3856

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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