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Western blot analysis in mouse liver tissue lysates (35ug/lane).
COL18A1 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in mouse liver tissue lysates (35ug/lane).

COL18A1 Antibody

CATALOG NUMBER: 55-358

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This COL18A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1311-1339 amino acids from the Central region of human COL18A1.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
Predicted Molecular Weight:
178 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
COL18A1
Additional Names:
Collagen alpha-1(XVIII) chain, Endostatin, COL18A1
Protein Accession Number:
P39060
Protein Gi Number:
215274264
Ncbi Gene Id Number:
80781
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
COL18A1 is the alpha chain of type XVIII collagen.This collagen is one of the multiplexins, extracellular matrixproteins that contain multiple triple-helix domains (collagenousdomains) interrupted by non-collagenous domains. Theproteolytically produced C-terminal fragment of type XVIII collagenis endostatin, a potent antiangiogenic protein. Mutations in thisgene are associated with Knobloch syndrome. The main features ofthis syndrome involve retinal abnormalities, so type XVIII collagenmay play an important role in retinal structure and in neural tubeclosure.
Background Reference 1:
Hamano, Y., et al. J. Am. Soc. Nephrol. 21(9):1445-1455(2010)
Background Reference 2:
Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)
Background Reference 3:
Lee, K.S., et al. Tumour Biol. 31(3):165-170(2010)
Background Reference 4:
Faye, C., et al. Biochem. J. 427(3):467-475(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

55-358

List Size:
400 ul

List Price:

$495.00

Datasheet
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