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Western blot analysis in human placenta tissue lysates (35ug/lane).
COPS7A Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in human placenta tissue lysates (35ug/lane).

COPS7A Antibody

CATALOG NUMBER: 56-662

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This COPS7A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the C-terminal region of human COPS7A.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
30 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
COPS7A
Additional Names:
COP9 signalosome complex subunit 7a, SGN7a, Signalosome subunit 7a, Dermal papilla-derived protein 10, JAB1-containing signalosome subunit 7a, COPS7A, CSN7A, DERP10
Protein Accession Number:
Q9UBW8
Protein Gi Number:
55976618
Ncbi Gene Id Number:
50813
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Background Reference 1:
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Background Reference 2:
Stelzl, U., et al. Cell 122(6):957-968(2005)
Background Reference 3:
Obuse, C., et al. Nat. Cell Biol. 6(11):1135-1141(2004)
Background Reference 4:
Wolf, D.A., et al. Nat. Cell Biol. 5(12):1029-1033(2003)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-662

List Size:
400 ul

List Price:

$495.00

Datasheet
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