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Western blot analysis of Coronin 7 in rat lung tissue lysate with Coronin 7 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of Coronin 7 in rat lung tissue with Coronin 7 antibody at 2.5 μg/mL.
Immunofluorescence of Coronin 7 in rat lung tissue with Coronin 7 antibody at 20 μg/mL.
Western blot analysis of Coronin 7 in rat lung tissue lysate with Coronin 7 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

Coronin 7 Antibody

CATALOG NUMBER: 6451

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (94%)
Immunogen:
Coronin 7 antibody was raised against an 17 amino acid synthetic peptide near the carboxy terminus of human Coronin 7.
The immunogen is located within the last 50 amino acids of Coronin 7.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
Coronin 7 antibody can be used for detection of Coronin 7 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Specificity:
Multiple isoforms of Coronin 7 are known to exist
Positive Control 1:
Cat. No. 1462 - Rat Lung Tissue Lysate
Purification:
Coronin 7 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Coronin 7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Coronin 7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CORO7
Additional Names:
Coronin 7 Antibody: CRN7, POD1, 0610011B16Rik, Coronin-7, 70 kDa WD repeat tumor rejection antigen homolog, Crn7
Protein Accession Number:
NP_078811
Protein Gi Number:
168229161
Ncbi Gene Id Number:
79585
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Coronin 7 Antibody: Coronins, such as Coronin 7, constitute an evolutionarily conserved family of WD-repeat actin-binding proteins whose function is thought to be regulating the cytoskeleton. Unlike other cytoplasmically localized Coronins, Coronin 7 localizes in part to the Golgi complex and is thought to play a role in Golgi complex morphology and function. Other experiments indicate that Coronin 7 interacts with the anti-proliferative protein TOB1 and enhances its degradation though the SCF ubiquitin ligase (E3) complex.
Background Reference 1:
Rybakin V, Stumpf N, Schulze A, et al. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus. FEBS Lett. 2004; 573:161-7.
Background Reference 2:
Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi. J. Biol. Chem. 2006; 281:31070-8.
Background Reference 3:
Watanabe M, Suzuki T, Kim M, et al. Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob. FEBS Lett. 2011; 585:65-70.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6451

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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