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Western Blot at 1:1000 dilution Lane 1: 293 whole cell lysate Lane 2: Hela whole cell lysate Lysates/proteins at 20 ug per lane.
Western blot analysis in T47D cell line lysates (35ug/lane).
Western Blot at 1:1000 dilution Lane 1: 293 whole cell lysate Lane 2: Hela whole cell lysate Lysates/proteins at 20 ug per lane.

CTNNB1 Antibody

CATALOG NUMBER: 60-609

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Immunogen:
This CTNNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723-751 amino acids from the C-terminal region of human CTNNB1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
85 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CTNNB1
Additional Names:
Catenin beta-1, Beta-catenin, CTNNB1, CTNNB
Protein Accession Number:
P35222
Protein Gi Number:
461854
Ncbi Gene Id Number:
1499
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is part of a complex ofproteins that constitute adherens junctions (AJs). AJs arenecessary for the creation and maintenance of epithelial celllayers by regulating cell growth and adhesion between cells. Theencoded protein also anchors the actin cytoskeleton and may beresponsible for transmitting the contact inhibition signal thatcauses cells to stop dividing once the epithelial sheet iscomplete. Finally, this protein binds to the product of the APCgene, which is mutated in adenomatous polyposis of the colon.Mutations in this gene are a cause of colorectal cancer (CRC),pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer.Three transcript variants encoding the same protein have been foundfor this gene.
Background Reference 1:
Huang, W., et al. Mol. Cell. Biol. 30(19):4575-4594(2010)
Background Reference 2:
Chairoungdua, A., et al. J. Cell Biol. 190(6):1079-1091(2010)
Background Reference 3:
Mirza, M.K., et al. J. Exp. Med. 207(8):1675-1685(2010)
Background Reference 4:
Guo, Q., et al. Acta Biochim. Biophys. Sin. (Shanghai) 42(7):450-456(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-609

List Size:
400 ul

List Price:

$495.00

Datasheet
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