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Western blot analysis in HepG2 cell line lysates (35ug/lane).
Western blot analysis of CTPS2 using rabbit polyclonal CTPS2 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CTPS2 gene.
Western blot analysis in HepG2 cell line lysates (35ug/lane).

CTPS2 Antibody

CATALOG NUMBER: 56-805

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This CTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 450-479 amino acids from the C-terminal region of human CTPS2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
66 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CTPS2
Additional Names:
CTP synthase 2, CTP synthetase 2, UTP--ammonia ligase 2, CTPS2
Protein Accession Number:
Q9NRF8
Protein Gi Number:
74752919
Ncbi Gene Id Number:
56474
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene catalyzes the formationof CTP from UTP with the concomitant deamination of glutamine toglutamate. This protein is the rate-limiting enzyme in thesynthesis of cytosine nucleotides, which play an important role invarious metabolic processes and provide the precursors necessaryfor the synthesis of RNA and DNA. Cancer cells that exhibitincreased cell proliferation also exhibit an increased activity ofthis encoded protein. Thus, this protein is an attractive targetfor selective chemotherapy. Three alternatively spliced transcriptvariants encoding the same protein have been described for thisgene.
Background Reference 1:
Kassel, K.M., et al. J. Biol. Chem. 285(44):33727-33736(2010)
Background Reference 2:
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Background Reference 3:
Han, G.S., et al. J. Biol. Chem. 280(46):38328-38336(2005)
Background Reference 4:
Ross, M.T., et al. Nature 434(7031):325-337(2005)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-805

List Size:
400 ul

List Price:

$495.00

Datasheet
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