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Western blot analysis of Cyclin O in mouse bladder tissue lysate with Cyclin O antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of Cyclin O in mouse bladder tissue lysate with Cyclin O antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

Cyclin O Antibody

CATALOG NUMBER: 3859

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Cyclin O antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human Cyclin O.
The immunogen is located within the first 50 amino acids of Cyclin O.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
Cyclin O antibody can be used for the detection of Cyclin O by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Specificity:
At least two isoforms of Cyclin O are known to exist; this antibody will recognize both isoforms.
Positive Control 1:
Cat. No. 1410 - Mouse Bladder Tissue Lysate
Predicted Molecular Weight:
39 kDa
Purification:
Cyclin O Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Cyclin O Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Cyclin O antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CCNO
Additional Names:
Cyclin O Antibody: CCNU, UDG2, Cyclin-O
Protein Accession Number:
NP_066970
Protein Gi Number:
153791755
Ncbi Gene Id Number:
10309
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Cyclin O Antibody: Cyclin O, also known as CCNO, has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to instrinsic apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Supression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. Note: this gene, which had a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase. A later publication identified this gene's product as a cyclin protein family member.
Background Reference 1:
Roig MB, Roset R, Ortet L, et al. Identification of a novel cyclin required for the intrinsic apoptosis pathway in lymphoid cells. Cell Death Diff. 2009; 16:230-43.
Background Reference 2:
Muller SJ and Caradonna S. Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase. Biochim. Biophys. Acta 1991; 1088:197-207.
Background Reference 3:
Muller SJ and Caradonna S. Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase. J. Biol. Chem. 1993; 268:1310-9

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

3859

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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