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Western Blot at 1:1000 dilution + K562 whole cell lysate Lysates/proteins at 20 ug per lane.
CYP2D6 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western Blot at 1:1000 dilution + K562 whole cell lysate Lysates/proteins at 20 ug per lane.

CYP2D6 Antibody

CATALOG NUMBER: 57-786

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This CYP2D6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-105 amino acids from the N-terminal region of human CYP2D6.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
56 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CYP2D6
Additional Names:
Cytochrome P450 2D6, CYPIID6, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CYP2DL1
Protein Accession Number:
P10635
Protein Gi Number:
84028191
Ncbi Gene Id Number:
1565
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.This protein localizes to the endoplasmic reticulum and is known tometabolize as many as 20% of commonly prescribed drugs. Itssubstrates include debrisoquine, an adrenergic-blocking drug;sparteine and propafenone, both anti-arrythmic drugs; andamitryptiline, an anti-depressant. The gene is highly polymorphicin the population; certain alleles result in the poor metabolizerphenotype, characterized by a decreased ability to metabolize theenzyme's substrates. The gene is located near two cytochrome P450pseudogenes on chromosome 22q13.1. Alternatively spliced transcriptvariants encoding different isoforms have been found for this gene.
Background Reference 1:
Abduljalil, K., et al. Clin. Pharmacol. Ther. 88(5):643-651(2010)
Background Reference 2:
Novalbos, J., et al.Clin Psychopharmacol 30(5):504-511(2010)
Background Reference 3:
Thompson, A.M., et al. Breast Cancer Res. Treat. (2010) In press :
Background Reference 4:
Gonzalez-Tejera, G., et al.R Health Sci29(3):299-304(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-786

List Size:
400 ul

List Price:

$495.00

Datasheet
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