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Western blot analysis of CYP2R1 Antibody in NCI-H460 cell line(lane 1) and mouse liver tissue(lane 2) lysates (35ug/lane)
Formalin-fixed and paraffin-embedded human brain tissue reacted with CYP2R1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Western blot analysis of CYP2R1 Antibody in NCI-H460 cell line(lane 1) and mouse liver tissue(lane 2) lysates (35ug/lane)

CYP2R1 Antibody

CATALOG NUMBER: 63-274

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This CYP2R1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-180 amino acids from the Central region of human CYP2R1.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
57 kDa
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CYP2R1
Additional Names:
Vitamin D 25-hydroxylase, Cytochrome P450 2R1, CYP2R1
Protein Accession Number:
Q6VVX0
Protein Gi Number:
62286619
Ncbi Gene Id Number:
120227
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor. A mutation in CYP2R1 gene has been associated with selective 25-hydroxyvitamin D deficiency.
Background Reference 1:
Ramos-Lopez,E., Diabetes Obes Metab 10 (8), 683-685 (2008)
Background Reference 2:
Strushkevich,N., J. Mol. Biol. 380 (1), 95-106 (2008)
Background Reference 3:
Ramos-Lopez,E., Diabetes Metab. Res. Rev. 23 (8), 631-636 (2007)
Background Reference 4:
Nelson,D.R., Pharmacogenetics 14 (1), 1-18 (2004)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

63-274

List Size:
400 ul

List Price:

$495.00

Datasheet
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