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Western blot detection of DC-SIGN in human uterus tissue lysate at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of DC-SIGN in human lymph node tissue with DC-SIGN antibody at 10 μg/mL.
Western blot detection of DC-SIGN in human uterus tissue lysate at (A) 1 and (B) 2 μg/mL.
Trial Size

DC-SIGN Antibody [8B6]

CATALOG NUMBER: PM-2348

Clonality:
Monoclonal
Tested Applications:
ELISA, IHC-P, WB
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Immunogen:
A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC-P, WB
Application Note:
DC-SIGN antibody can be used for detection of DC-SIGN in Western Blot at 1 - 2 mg/mL and in immunohistochemistry at 5 - 10 mg/mL.
Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1384 - Human Uterus Tissue Lysate
Positive Control 2:
Cat. No. 1369 - Human Lymph node Tissue Lysate
Purification:
DC-SIGN Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Clonality:
Monoclonal
Isotype:
IgG1,k
physical-state:
Liquid
Buffer:
DC-SIGN Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
DC-SIGN monoclonal antibody can be stored at -20°C, stable for one year.
Ncbi Official Symbol:
CD209
Additional Names:
DC-SIGN Antibody [8B6] : CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1
Protein Accession Number:
Q9NNX6
Protein Gi Number:
46396012
Ncbi Gene Id Number:
30835
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
Background Reference 1:
Geijtenbeek TB, Kwon DS, Torensma R, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000; 100:587-97.
Background Reference 2:
Pohlmann S, Baribaud F, Lee B, et al. DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. J. Virol. 2001;75:4664-72.
Background Reference 3:
Geijtenbeek TB, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000; 100:575-85.
Background Reference 4:
Soilleux EJ, Barten R, Trowsdale J. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. J. Immunol. 2000; 165:2937-42.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

PM-2348

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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