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Western blot analysis in mouse heart tissue lysates (35ug/lane).
DCC Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in mouse heart tissue lysates (35ug/lane).

DCC Antibody

CATALOG NUMBER: 56-355

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Rat
Immunogen:
This DCC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 643-670 amino acids from the Central region of human DCC.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
158 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
DCC
Additional Names:
Netrin receptor DCC, Colorectal cancer suppressor, Immunoglobulin superfamily DCC subclass member 1, Tumor suppressor protein DCC, DCC, IGDCC1
Protein Accession Number:
P43146
Protein Gi Number:
296434474
Ncbi Gene Id Number:
1630
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a netrin 1 receptor. The transmembraneprotein is a member of the immunoglobulin superfamily of celladhesion molecules, and mediates axon guidance of neuronal growthcones towards sources of netrin 1 ligand. The cytoplasmic tailinteracts with the tyrosine kinases Src and focal adhesion kinase(FAK, also known as PTK2) to mediate axon attraction. The proteinpartially localizes to lipid rafts, and induces apoptosis in theabsence of ligand. The protein functions as a tumor suppressor, andis frequently mutated or downregulated in colorectal cancer andesophageal carcinoma.
Background Reference 1:
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Background Reference 2:
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 3:
Srour, M., et al. Science 328 (5978), 592 (2010) :
Background Reference 4:
Docherty, S.J., et al. BMC Genet. 11, 61 (2010) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-355

List Size:
400 ul

List Price:

$495.00

Datasheet
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