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Western blot analysis of DCNP1 in mouse skeletal muscle tissue lysate with DCNP1 antibody at (A) 1 and (B) 2 μg/ml.
Immunohistochemistry of DCNP1 in mouse skeletal muscle tissue with DCNP1 antibody at 5 μg/ml.
Immunofluorescence of DCNP1 in mouse skeletal muscle tissue with DCNP1 antibody at 20 μg/ml.
Western blot analysis of DCNP1 in mouse skeletal muscle tissue lysate with DCNP1 antibody at (A) 1 and (B) 2 μg/ml.
Trial Size

DCNP1 Antibody

CATALOG NUMBER: 7769

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
DCNP1 antibody was raised against an 18 amino acid peptide near the amino terminus of human DCNP1.
The immunogen is located within the first 50 amino acids of DCNP1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
DCNP1 antibody can be used for detection of DCNP1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Specificity:
DCNP1 antibody is human, mouse and rat reactive.
Positive Control 1:
Cat. No. 1407 - Mouse Skeletal Muscle Tissue Lysate
Predicted Molecular Weight:
Predicted: 27 kDa
Observed: 24 kDa
Purification:
DCNP1 antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
DCNP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
DCNP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
C5orf20
Additional Names:
DCNP1 Antibody: DCNP1, C5orf20, Dendritic cell nuclear protein 1
Protein Accession Number:
NP_570900
Protein Gi Number:
18677770
Ncbi Gene Id Number:
140947
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The DCNP1 (dendritic cell nuclear protein 1) gene is specifically expressed in dendritic cells, potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response (1). It is localized mainly in the perinucleus. One of the alleles (A/T) of this gene causes premature translation termination at aa 117 and has been associated with an increased prevalence of major depression in humans (2,3). DCNP1 may play a role in the pathogenesis of depressive disorders by enhancing corticotropin-releasing hormone expression in the hypothalamic paraventricular nucleus (4).
Background Reference 1:
Masuda M, Senju S, Fujii Si S, et al. Identification and immunocytochemical analysis of DCNP1, a dendritic cell-associated nuclear protein. Biochem. Biophys. Res. Commun. 2002; 290:1022-9.
Background Reference 2:
Willis-Owen SA, Shifman S, Copley RR, et al. DCNP1: a novel candidate gene for major depression. Mol. Psychiatry 2006; 11:121-2.
Background Reference 3:
Bosker FJ, Hartman CA, Nolte IM, et al. Poor replication of candidate genes for major depressive disorder using genome-wide association data. Mol. Psychiatry 2011; 16:516-32.
Background Reference 4:
Zhou T, Wang S, Ren H, et al. Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression. Brain 2010; 133:3069-79.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7769

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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