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Western blot analysis of DcR2 in HeLa whole cell lysate with DcR2 antibody at 1 μg/mL.
Immunocytochemistry staining of HeLa cells using DcR2 antibody at 10μg/mL.
Immunohistochemistry of DcR2 in mouse kidney node tissue with DcR2 antibody at 2.5 μg/ml.
Immunofluorescence of DcR2 in mouse kidney tissue withDcR2 antibody at 20 μg/ml.<br><br>Green: DcR2 Antibody (2021) <br> Blue: DAPI staining
Western blot analysis of DcR2 in HeLa whole cell lysate with DcR2 antibody at 1 μg/mL.
Green Product
Trial Size

DcR2 Antibody

CATALOG NUMBER: 2021

Clonality:
Polyclonal
Tested Applications:
ELISA, ICC, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
DcR2 antibody was raised against a 15 amino acid peptide near the center of human DcR2.
The immunogen is located within amino acids 230 - 280 of DcR2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, ICC, IF, IHC-P, WB
Application Note:
DcR2 antibody can be used for detection of DcR2 expression by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL and Immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in mouse samples; Immunocytochemistry in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1201 - HeLa Cell Lysate
Positive Control 2:
Cat. No. 17-001 - HeLa Cell Slide
Predicted Molecular Weight:
Predicted: 36 kDa
Observed: 36 kDa
Validation:

KD validation (Figure 7): Anti-ASC antibody (2287) specificity was further verified by ASC specific knockdown. ASC signal in THP-1 cells transfected with ASC siRNAs was disrupted in comparison with that in cells transfected with GFP siRNAs.

Purification:
DcR2 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
DcR2 Antibody is supplied in PBS containing ≤0.09% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
DcR2 antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
TNFRSF10D
Additional Names:
DcR2 Antibody: DCR2, CD264, TRUNDD, TRAILR4, TRAIL-R4, DCR2, UNQ251/PRO288, Tumor necrosis factor receptor superfamily member 10D, Decoy receptor 2, DcR2
Protein Accession Number:
Q9UBN6
Protein Gi Number:
18203495
Ncbi Gene Id Number:
8793
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
DcR2 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.
Background Reference 1:
Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science 1997; 276:111-3.
Background Reference 2:
Pan G, Ni J, Wei YF, Yu G, et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 1997; 277:815-8.
Background Reference 3:
Sheridan JP, Marsters SA, Pitti RM, et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 1997; 277:818-21.
Background Reference 4:
Marsters SA, Sheridan JP, Pitti RM, et al. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr. Biol. 1997; 7:1003-6.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

2021

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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