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Western blot analysis of DELE in rat brain tissue lysate with DELE antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of DELE in human brain tissue with DELE antibody at 20 μg/mL.
Western blot analysis of DELE in rat brain tissue lysate with DELE antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Trial Size

DELE Antibody

CATALOG NUMBER: 6919

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Mouse: (71%)
Immunogen:
DELE antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DELE.
The immunogen is located within the first 50 amino acids of DELE.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, WB
Application Note:
DELE antibody can be used for detection of DELE by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1463 - Rat Brain Tissue Lysate
Positive Control 2:
Cat. No. 10-301 - Human Brain Tissue Slide
Purification:
DELE Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
DELE Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
DELE antibody can be stored at 4°C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
KIAA0141
Additional Names:
DELE Antibody: DELE, DELE, Death ligand signal enhancer
Protein Accession Number:
NP_055588
Protein Gi Number:
217330656
Ncbi Gene Id Number:
9812
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
DELE Antibody: DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-α and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-α, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.
Background Reference 1:
Harada T, Iwai A, Miyazaki T. Identification of DELE, a novel DAP-binding protein which is crucial for death receptor-mediated apoptosis induction. Apoptosis 2010; 15:1247-55.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6919

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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