DHPS Antibody

CATALOG NUMBER: 58-908

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This DHPS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-43 amino acids from the N-terminal region of human DHPS.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
41 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
DHPS
Additional Names:
Deoxyhypusine synthase, DHS, DHPS, DS
Protein Accession Number:
P49366
Protein Gi Number:
1352267
Ncbi Gene Id Number:
1725
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The unusual amino acid hypusine is formedposttranslationally and is only found in a single cellular protein,eukaryotic translation initiation factor 5A. In the first step ofhypusine biosynthesis, deoxyhypusine synthase catalyzes theNAD-dependent transfer of the butylamine moiety of spermidine tothe epsilon-amino group of a specific lysine residue of the EIF5Aprecursor protein to form the intermediate deoxyhypusine residue.This gene consists of nine exons spanning 6.6 kb. Three transcriptvariants have been isolated. However, only transcript variant 1encodes an active protein. The shorter variants may act asmodulating factors of DHPS activity.
Background Reference 1:
Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009)
Background Reference 2:
Alker, A.P., et al. Trop. Med. Int. Health 13(11):1384-1391(2008)
Background Reference 3:
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Background Reference 4:
Lamesch, P., et al. Genomics 89(3):307-315(2007)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-908

List Size:
400 ul

List Price:

$495.00

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