DNMT3L Antibody

Background:

CpG methylation is an epigenetic modification that isimportant for embryonic development, imprinting, and X-chromosomeinactivation. Studies in mice have demonstrated that DNAmethylation is required for mammalian development. This geneencodes a nuclear protein with similarity to DNAmethyltransferases. This protein is not thought to function as aDNA methyltransferase as it does not contain the amino acidresidues necessary for methyltransferase activity. However, thisprotein does stimulate de novo methylation by DNA cytosinemethyltransferase 3 alpha and it is thought to be required for theestablishment of maternal genomic imprints. This protein alsomediates transcriptional repression through interaction withhistone deacetylase 1. Alternative splicing results in twotranscript variants. An additional splice variant has beendescribed but its biological validity has not been determined.