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Western blot analysis in CEM cell line lysates (35ug/lane).
DOK3 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in CEM cell line lysates (35ug/lane).

DOK3 Antibody

CATALOG NUMBER: 56-195

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This DOK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-321 amino acids from the C-terminal region of human DOK3.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
53 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
DOK3
Additional Names:
Docking protein 3, Downstream of tyrosine kinase 3, DOK3
Protein Accession Number:
Q7L591
Protein Gi Number:
84029599
Ncbi Gene Id Number:
79930
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function (By similarity).
Background Reference 1:
Berger, A.H., et al. Nat. Genet. 42(3):216-223(2010)
Background Reference 2:
Senis, Y.A., et al. J. Thromb. Haemost. 7(10):1718-1726(2009)
Background Reference 3:
Honma, M., et al. Genes Cells 11(2):143-151(2006)
Background Reference 4:
Robson, J.D., et al. Mol. Cell. Biol. 24(6):2332-2343(2004)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-195

List Size:
400 ul

List Price:

$495.00

Datasheet
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