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Western blot of 5 μg of bovine adrenal medulla lysate showing specific immunolabeling of the ~55k DOPA decarboxylase protein.
Western blot of 5 μg of bovine adrenal medulla lysate showing specific immunolabeling of the ~55k DOPA decarboxylase protein.

DOPA Decarboxylase Antibody

CATALOG NUMBER: 50-202

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Bovine, Dog, Goat, Human, Rabbit, Rat, Sheep
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Bovine, Dog, Goat, Human, Rabbit, Rat, Sheep
Immunogen:
Peptide from N-terminus region of human DOPA decarboxylase (DDC), conjugated to keyhole limpet hemocyanin (KLH).
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
The antibody has been directly tested for reactivity in Western blots in bovine, canine, guinea pig, human, rabbit, rat and sheep tissues.
Predicted Molecular Weight:
55
Purification:
Affinity Purified
Clonality:
Polyclonal
physical-state:
Liquid
Concentration:
batch dependent
Storage Conditions:
DOPA Decarboxylase antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Ncbi Official Symbol:
DDC
Protein Accession Number:
P20711
Protein Gi Number:
311033369
Ncbi Gene Id Number:
1644
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
DOPA decarboxylase (aromatic L-amino acid decarboxylase, AADC; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin (Waymire and Haycock, 2002; Berry et al., 1996; Haycock et al., 2003). It is also involved in the biosynthesis of trace amines. DDC antibodies can therefore be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999).
Background Reference 1:
Berry MD, Juorio AV, Li XM, Boulton AA (1996) Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme. Neurochem Res 21:1075-1087.
Background Reference 2:
Haycock JW, Becker L, Ang L, Furukawa Y, Hornykiewicz O, Kish SJ (2003) Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. J Neurochem 87:574-585.
Background Reference 3:
Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001)Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567.

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

50-202

List Size:
0.1 mL

List Price:

$540.00

Datasheet
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