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Western blot of human caudate lysate showing specific immunolabeling of the ~88k DAT protein.
Western blot of human caudate lysate showing specific immunolabeling of the ~88k DAT protein.

Dopamine Transporter Antibody

CATALOG NUMBER: 50-204

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
Peptide from the intracellular C-terminus region of human dopamine transporter (DAT), conjugated to keyhole limpet hemocyanin (KLH).
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Application Note:
The antibody has been tested in Western blots of SDS-solubilized human and mouse striatal samples and in IHC applications with monkey (Macaque) brain sections.
Predicted Molecular Weight:
88
Purification:
Affinity Purified
Clonality:
Polyclonal
Physical State:
Liquid
Concentration:
batch dependent
Storage Conditions:
Dopamine Transporter antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Ncbi Official Symbol:
SLC6A3
Protein Accession Number:
Q01959
Protein Gi Number:
266667
Ncbi Gene Id Number:
6531
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The dopamine transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. DAT antibodies and antibodies for other markers of catecholamine biosynthesis are widely used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). Levels of DAT protein expression are altered by chronic drug administration (Wilson et al., 1996).
Background Reference 1:
Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567.
Background Reference 2:
Wilson JM, Kalasinsky KS, Levey AI, Bergeron C, Reiber G, Anthony RM, Schmunk GA, Shannak K, Haycock JW, Kish SJ (1996) Striatal dopamine nerve terminal markers in human, chronic methamphetamine users. Nat Med 2:699-703.
Background Reference 3:
Zhu MY, Klimek V, Haycock JW, Ordway GA (2000) Quantitation of tyrosine hydroxylase protein in the locus coeruleus from postmortem human brain. J Neurosci Meth 99:37-44.

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

50-204

List Size:
0.1 mL

List Price:

$540.00

Datasheet
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