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Western blot analysis in K562 cell line lysates (35ug/lane).
DSG1 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in K562 cell line lysates (35ug/lane).

DSG1 Antibody

CATALOG NUMBER: 57-728

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This DSG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 471-499 amino acids from the Central region of human DSG1.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
114 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
DSG1
Additional Names:
Desmoglein-1, Cadherin family member 4, Desmosomal glycoprotein 1, DG1, DGI, Pemphigus foliaceus antigen, DSG1, CDHF4
Protein Accession Number:
Q02413
Protein Gi Number:
292495005
Ncbi Gene Id Number:
1828
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Desmosomes are cell-cell junctions between epithelial,myocardial and certain other cell types. Desmoglein 1 is acalcium-binding transmembrane glycoprotein component of desmosomesin vertebrate epithelial cells. Currently, three desmogleinsubfamily members have been identified and all are members of thecadherin cell adhesion molecule superfamily. These desmoglein genefamily members are located in a cluster on chromosome 18. Theprotein encoded by this gene has been identified as the autoantigenof the autoimmune skin blistering disease pemphigus foliaceus.
Background Reference 1:
Rothenberg, M.E., et al. Nat. Genet. 42(4):289-291(2010)
Background Reference 2:
Naoe, Y., et al. J. Dermatol. Sci. 57(3):192-198(2010)
Background Reference 3:
Qian, Y., et al. J. Invest. Dermatol. 129(12):2823-2834(2009)
Background Reference 4:
Spindler, V., et al. J. Biol. Chem. 284(44):30556-30564(2009)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-728

List Size:
400 ul

List Price:

$495.00

Datasheet
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