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Western blot analysis in A375 cell line lysates (35ug/lane).
Western blot analysis in A375 cell line lysates (35ug/lane).

DUSP10 Antibody

CATALOG NUMBER: 60-804

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This DUSP10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-232 amino acids from the Central region of human DUSP10.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
53 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
DUSP10
Additional Names:
Dual specificity protein phosphatase 10, Mitogen-activated protein kinase phosphatase 5, MAP kinase phosphatase 5, MKP-5, DUSP10, MKP5
Protein Accession Number:
Q9Y6W6
Protein Gi Number:
20138090
Ncbi Gene Id Number:
11221
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Dual specificity protein phosphatases inactivate theirtarget kinases by dephosphorylating both thephosphoserine/threonine and phosphotyrosine residues. Theynegatively regulate members of the MAPK superfamily (MAPK/ERK,SAPK/JNK, p38), which is associated with cellular proliferation anddifferentiation. Different members of this family of dualspecificity phosphatases show distinct substrate specificities forMAPKs, different tissue distribution and subcellular localization,and different modes of inducibility of their expression byextracellular stimuli. This gene product binds to and inactivatesp38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization isunique; it is evenly distributed in both the cytoplasm and thenucleus. This gene is widely expressed in various tissues andorgans, and its expression is elevated by stress stimuli. Threetranscript variants encoding two different isoforms have been foundfor this gene.
Background Reference 1:
Bailey, S.D., et al. Diabetes Care (2010) In press :
Background Reference 2:
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 3:
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Background Reference 4:
Tephly, L.A., et al. Am. J. Respir. Cell Mol. Biol. 39(1):113-123(2008)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-804

List Size:
400 ul

List Price:

$495.00

Datasheet
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