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Western blot analysis in mouse cerebellum tissue lysates (35ug/lane).
Western blot analysis in mouse cerebellum tissue lysates (35ug/lane).

DUSP12 Antibody

CATALOG NUMBER: 58-792

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This DUSP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 162-191 amino acids from the Central region of human DUSP12.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
38 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
DUSP12
Additional Names:
Dual specificity protein phosphatase 12, Dual specificity tyrosine phosphatase YVH1, DUSP12
Protein Accession Number:
Q9UNI6
Protein Gi Number:
9973073
Ncbi Gene Id Number:
11266
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is a member of the dualspecificity protein phosphatase subfamily. These phosphatasesinactivate their target kinases by dephosphorylating both thephosphoserine/threonine and phosphotyrosine residues. Theynegatively regulate members of the mitogen-activated protein (MAP)kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associatedwith cellular proliferation and differentiation. Different membersof the family of dual specificity phosphatases show distinctsubstrate specificities for various MAP kinases, different tissuedistribution and subcellular localization, and different modes ofinducibility of their expression by extracellular stimuli. Thisgene product is the human ortholog of the Saccharomyces cerevisiaeYVH1 protein tyrosine phosphatase. It is localized predominantly inthe nucleus, and is novel in that it contains, and is regulated bya zinc finger domain.
Background Reference 1:
Biernacki, M.A., et al. Cancer Res. 70(3):906-915(2010)
Background Reference 2:
Bonham, C.A., et al. J. Biol. Chem. 284(34):22853-22864(2009)
Background Reference 3:
Sharda, P.R., et al. Biochem. J. 418(2):391-401(2009)
Background Reference 4:
Gao, F., et al. Zhonghua Yi Xue Za Zhi 88(32):2250-2253(2008)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-792

List Size:
400 ul

List Price:

$495.00

Datasheet
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