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The purity of rhECAD Fc Chimera was determined by SDS-PAGE of reduced (+) and non-reduced (-) rhECAD Fc Chimera and staining overnight with Coomassie Blue.
The purity of rhECAD Fc Chimera was determined by SDS-PAGE of reduced (+) and non-reduced (-) rhECAD Fc Chimera and staining overnight with Coomassie Blue.

E Cadherin Recombinant Protein

CATALOG NUMBER: 96-253

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Gln 23 - Pro 621
Fusion Tag:
C-Fc Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
92.4 kDa
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
50 mM tris, 100 mM glycine, pH7.5
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
CDH1
Additional Names:
Cadherin-1, CDH1, CD324, E-cadherin, Arc-1, ECAD, LCAM, UVO
Protein Accession Number:
AAI41839
Ncbi Gene Id Number:
999
Background:
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-1 (CDH1) is also known as epithelial cadherin (E-cadherin), CD_antigen (CD324), Uvomorulin (UVO) ECAD and CDHE, CDH1 / CD324 contains 5 cadherin domains. CDH1 / CD324 / ECAD is expressed in non-neural epithelial tissues. CDH1 / E-CAD is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells and has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad promotes non-amyloidogenic degradation of Abeta precursors and has a strong inhibitory effect on APP C99 and C83 production. Defects in CDH1 / CD324 / ECAD are the cause of hereditary diffuse gastric cancer (HDGC).
Background Reference 1:
Agiostratidou G., et al., 2006, J. Neurochem. 96:1182-1188.
Background Reference 2:
Meng Y.G., et al., 2007, Cell Res. 17:869-880.
Background Reference 3:
Yoon K.-A., et al., 1999, J. Hum. Genet. 44:177-180.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-253

List Size:
0.1 mg

List Price:

$495.00

Datasheet
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