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Ebolavirus (subtype Bundibugyo,strain Uganda 2007) GP1 on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Ebolavirus (subtype Bundibugyo,strain Uganda 2007) GP1 on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Ebolavirus Glycoprotein Recombinant Protein

CATALOG NUMBER: 97-049

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Ebolavirus
source-species:
HEK293 cells
Recombinant Protein Sequence:
Ile 33 - Gln 304
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
31.8 kDa
Purity:
>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
Glycoprotein / GP (virus)
Additional Names:
Ebolavirus Glycoprotein
Protein Accession Number:
ACI28624
Ncbi Gene Id Number:
9487265
Background:
EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.
Background Reference 1:
Saeed M.F., et al., 2010, PLoS Pathog. 6:0-0.
Background Reference 2:
Marzi A., et al., 2006, J. Virol. 80:6305-6317.
Background Reference 3:
Chandran K., et al., 2005, Science 308:1643-1645.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

97-049

List Size:
0.1 mg

List Price:

$495.00

Datasheet
Shipping Info

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