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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
Western blot analysis in NCI-H460 cell line lysates (35ug/lane).

EDN3 Antibody

CATALOG NUMBER: 55-714

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This EDN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human EDN3.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
25 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
EDN3
Additional Names:
Endothelin-3, ET-3, Preproendothelin-3, PPET3, EDN3
Protein Accession Number:
P14138
Protein Gi Number:
119618
Ncbi Gene Id Number:
1908
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is a member of theendothelin family. Endothelins are endothelium-derived vasoactivepeptides involved in a variety of biological functions. The activeform of this protein is a 21 amino acid peptide processed from theprecursor protein. The active peptide is a ligand for endothelinreceptor type B (EDNRB). The interaction of this endothelin withEDNRB is essential for development of neural crest-derived celllineages, such as melanocytes and enteric neurons. Mutations inthis gene and EDNRB have been associated with Hirschsprung disease(HSCR) and Waardenburg syndrome (WS), which are congenitaldisorders involving neural crest-derived cells. Four alternativelyspliced transcript variants encoding three distinct isoforms havebeen observed.
Background Reference 1:
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Background Reference 2:
Darrah, R., et al. Physiol. Genomics 41(1):71-77(2010)
Background Reference 3:
Sanchez-Mejias, A., et al. Genet. Med. 12(1):39-43(2010)
Background Reference 4:
Broasca, V., et al. RomMorphol Embryol 51(2):283-288(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

55-714

List Size:
400 ul

List Price:

$495.00

Datasheet
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