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Western blot analysis of lysed extracts from HUVEC cells untreated or treated with EGF using EGFR (Phospho-Ser1070).
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using EGFR (Phospho-Ser1070).
Western blot analysis of lysed extracts from HUVEC cells untreated or treated with EGF using EGFR (Phospho-Ser1070).

EGFR (phospho Ser1070) Antibody

CATALOG NUMBER: 79-141

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
EGFR (Phospho-Ser1070) antibody was raised against a peptide sequence around phosphorylation site of serine 1070 (R-Y-S (p) -S-D) derived from Human EGFR.
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Specificity:
This antibody detects endogenous level of EGFR only when phosphorylated at serine1070.
Predicted Molecular Weight:
175 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
EGFR
Additional Names:
ERBB, HER1, mENA, ERBB1, PIG61, Receptor protein-tyrosine kinase ErbB-1, kinase EGFR
Protein Accession Number:
NP_005219.2
Protein Gi Number:
29725609
Ncbi Gene Id Number:
1956
Background:
Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.
Background Reference 1:
Feinmesser RL, et al. (1999) J Biol Chem; 274 (23): 16168-73. Gamou S, et al. (1995) FEBS Lett; 357 (2): 161-4. Gamou S, et al. (1994) J Cell Physiol; 158 (1): 151-9. Heisermann GJ, et al. (1988) J Biol Chem; 263 (26): 13152-8.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-141

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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