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Western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).
Western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).

EIF3C Antibody

CATALOG NUMBER: 58-434

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Rat, Xenopus, Human
Immunogen:
This EIF3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 538-566 amino acids from the Central region of human EIF3C.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
105 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
EIF3C
Additional Names:
Eukaryotic translation initiation factor 3 subunit C {ECO:0000255, HAMAP-Rule:MF_03002}, eIF3c {ECO:0000255, HAMAP-Rule:MF_03002}, Eukaryotic translation initiation factor 3 subunit 8 {ECO:0000255, HAMAP-Rule:MF_03002}, eIF3 p110 {ECO:0000255, HAMAP-Rule:MF_03002}, EIF3C {ECO:0000255, HAMAP-Rule:MF_03002}
Protein Accession Number:
Q99613
Protein Gi Number:
6685539
Ncbi Gene Id Number:
8663
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.
Background Reference 1:
Imielinski, M., et al. Nat. Genet. 41(12):1335-1340(2009)
Background Reference 2:
Zhou, M., et al. Proc. Natl. Acad. Sci. U.S.A. 105(47):18139-18144(2008)
Background Reference 3:
Masutani, M., et al. EMBO J. 26(14):3373-3383(2007)
Background Reference 4:
Damoc, E., et al. Mol. Cell Proteomics 6(7):1135-1146(2007)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-434

List Size:
400 ul

List Price:

$495.00

Datasheet
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