ENSA Antibody

CATALOG NUMBER: 55-188

Clonality:
Polyclonal
Tested Applications:
Flow, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Zebrafish, Pig, Rat, Xenopus
Immunogen:
This ENSA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the Central region of human ENSA.
Conjugate:
Unconjugated
Tested Applications:
Flow, WB
Application Note:
For WB starting dilution is: 1:1000
For FACS starting dilution is: 1:10~50
Predicted Molecular Weight:
13 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ENSA
Additional Names:
Alpha-endosulfine, ARPP-19e, ENSA
Protein Accession Number:
O43768
Ncbi Gene Id Number:
2029
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
ENSA belongs to a highlyconserved cAMP-regulated phosphoprotein (ARPP) family. This proteinwas identified as an endogenous ligand for the sulfonylureareceptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of theATP-sensitive potassium (KATP) channel, which is located on theplasma membrane of pancreatic beta cells and plays a key role inthe control of insulin release from pancreatic beta cells. Thisprotein is thought to be an endogenous regulator of KATP channels.In vitro studies have demonstrated that this protein modulatesinsulin secretion through the interaction with KATP channel, andthis gene has been proposed as a candidate gene for type 2diabetes.
Background Reference 1:
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Background Reference 2:
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Background Reference 3:
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Background Reference 4:
Gabrielsson, B.G., et al. Mol. Cell. Biochem. 258 (1-2), 65-71 (2004) :

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

55-188

List Size:
400 ul

List Price:

$495.00

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