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Western blot analysis of extracts from JK cells (Lane 2), using EPHA4 (Phospho-Tyr596) Antibody. The lane on the left is treated with antigen-specific peptide.
Western blot analysis of extracts from JK cells (Lane 2), using EPHA4 (Phospho-Tyr596) Antibody. The lane on the left is treated with antigen-specific peptide.

EPHA4 (phospho Tyr596) Antibody

CATALOG NUMBER: 79-943

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
EPHA4 (phospho Tyr596) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 596 (R-T-Y (p)-V-D) derived from Human EPHA4 .
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous levels of EPHA4 only when phosphorylated at tyrosine 596
Predicted Molecular Weight:
110 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
EPHA4
Additional Names:
EK8, hEK8, EPH-like kinase 8
Protein Accession Number:
NP_004429.1
Protein Gi Number:
1711371
Ncbi Gene Id Number:
2043
Background:
Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity.
Background Reference 1:
Rikova K., Cell 131:1190-1203(2007) [PubMed: 18083107].
Background Reference 2:
Richter M., J. Neurosci. 27:14205-14215(2007) [PubMed: 18094260].
Background Reference 3:
Fu W.Y., Nat. Neurosci. 10:67-76(2007) [PubMed: 17143272].

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-943

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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