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Epiregulin Recombinant Protein

CATALOG NUMBER: 40-149

Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
MVAQVSITKC SSDMNGYCLH GQCIYLVDMS QNYCRCEVGY TGVRCEHFFL
Biological Activity:
The ED50 was determined by its ability to inhibit IGF - II induced proliferation of MCF - 7 is ≤ 0.3 μg/mL in the presence of 15 ng/mL of human IGF - II.
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
physical-state:
Lyophilized
Storage Conditions:
The lyophilized Epiregulin recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Epiregulin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing Epiregulin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
EREG
Additional Names:
ER, Proepiregulin, EPR
Protein Accession Number:
NP_001423.1
Protein Gi Number:
4557567
Ncbi Gene Id Number:
2069
Background:
Epiregulin is an EGF related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes and in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence. Recombinant human Epiregulin is a 5.6 kDa monomeric protein, containing 50 amino residues, which corresponds to the mature secreted Epiregulin sequence.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

40-149

List Size:
0.005 mg, 0.025 mg

List Price:

Price range: $215.00 through $323.00

Datasheet
Shipping Info

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