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Western blot analysis of lysate from HT-29 cell line, using ERN2 Antibody at 1:1000.
Western blot analysis of ERN2 N-term in mouse stomach tissue lysates (35ug/lane)
Western blot analysis of lysate from HT-29 cell line, using ERN2 Antibody at 1:1000.

ERN2 Antibody

CATALOG NUMBER: 62-675

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This ERN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-72 amino acids from the N-terminal region of human ERN2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
102 kDa
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ERN2
Additional Names:
Serine/threonine-protein kinase/endoribonuclease IRE2, Endoplasmic reticulum-to-nucleus signaling 2, Inositol-requiring protein 2, hIRE2p, Ire1-beta, IRE1b, Serine/threonine-protein kinase, Endoribonuclease, 3126-, ERN2 (HGNC:16942)
Protein Accession Number:
Q76MJ5
Protein Gi Number:
327478597
Ncbi Gene Id Number:
10595
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
ERN2 induces translational repression through 28S ribosomal RNA cleavage in response to endoplasmic reticulum (ER) stress. This pro-apoptotic appears to play no role in the unfolded-protein response, unlike closely related proteins. Overexpression of ERN2 activates both BiP and CHOP expression, and also leads to the development of programmed cell death. It has been suggested that Ern2 plays a role in multiple facets of the ER stress response in mammalian cells.
Background Reference 1:
Iwawaki, T., et al., Nat. Cell Biol. 3(2):158-164 (2001).
Background Reference 2:
Niwa, M., et al., Cell 99(7):691-702 (1999).
Background Reference 3:
Wang, X.Z., et al., EMBO J. 17(19):5708-5717 (1998).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

62-675

List Size:
400 ul

List Price:

$495.00

Datasheet
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