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Western blot analysis in MCF-7 cell line lysates (35ug/lane).
Western blot analysis in MCF-7 cell line lysates (35ug/lane).

ERVWE1 Antibody

CATALOG NUMBER: 58-894

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This ERVWE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-521 amino acids from the C-terminal region of human ERVWE1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
60 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
ERVW-1
Additional Names:
Syncytin-1, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, HERV-W_7q212 provirus ancestral Env polyprotein, Syncytin, Surface protein, SU, gp50, Transmembrane protein, TM, gp24, ERVW-1, ERVWE1
Protein Accession Number:
Q9UQF0
Protein Gi Number:
47605755
Ncbi Gene Id Number:
30816
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Many different human endogenous retrovirus (HERV) familiesare expressed in normal placental tissue at high levels, suggestingthat HERVs are functionally important in reproduction. This gene ispart of an HERV provirus on chromosome 7 that has inactivatingmutations in the gag and pol genes. This gene is the envelopeglycoprotein gene which appears to have been selectively preserved.The gene's protein product is expressed in the placentalsyncytiotrophoblast and is involved in fusion of thecytotrophoblast cells to form the syncytial layer of the placenta.The protein has the characteristics of a typical retroviralenvelope protein, including a furin cleavage site that separatesthe surface (SU) and transmembrane (TM) proteins which form aheterodimer. Alternatively spliced transcript variants encoding thesame protein have been found for this gene.
Background Reference 1:
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Background Reference 2:
Oppelt, P., et al. Gynecol. Endocrinol. 25(11):741-747(2009)
Background Reference 3:
Gimenez, J., et al. DNA Res. 16(4):195-211(2009)
Background Reference 4:
Larsen, J.M., et al. Cancer Lett. 280(1):44-49(2009)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-894

List Size:
400 ul

List Price:

$495.00

Datasheet
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