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Western blot analysis in WiDr cell line lysates (35ug/lane).
Western blot analysis in WiDr cell line lysates (35ug/lane).

FADD Antibody

CATALOG NUMBER: 60-625

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This FADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the Central region of human FADD.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
23 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
FADD
Additional Names:
FAS-associated death domain protein, FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, Protein FADD, FADD, MORT1
Protein Accession Number:
Q13158
Protein Gi Number:
2498355
Ncbi Gene Id Number:
8772
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The protein encoded by this gene is an adaptor moleculethat interacts with various cell surface receptors and mediatescell apoptotic signals. Through its C-terminal death domain, thisprotein can be recruited by TNFRSF6/Fas-receptor, tumor necrosisfactor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus itparticipates in the death signaling initiated by these receptors.Interaction of this protein with the receptors unmasks theN-terminal effector domain of this protein, which allows it torecruit caspase-8, and thereby activate the cysteine proteasecascade. Knockout studies in mice also suggest the importance ofthis protein in early T cell development.
Background Reference 1:
Hindryckx, P., et al. J. Immunol. 185(10):6306-6316(2010)
Background Reference 2:
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
Background Reference 3:
Papoff, G., et al. Biochim. Biophys. Acta 1803(8):898-911(2010)
Background Reference 4:
Li, P., et al. J. Biol. Chem. 285(29):22713-22722(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-625

List Size:
400 ul

List Price:

$495.00

Datasheet
Shipping Info

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