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Western blot analysis of extracts from Jurkat cells treated with PMA using FADD (Phospho-Ser191) Antibody. The lane on the right is treated with the antigen-specific peptide.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using FADD (Phospho-Ser191) antibody (left) or the same antibody preincubated with blocking peptide (right).
Western blot analysis of extracts from Jurkat cells treated with PMA using FADD (Phospho-Ser191) Antibody. The lane on the right is treated with the antigen-specific peptide.

FADD (phospho Ser191) Antibody

CATALOG NUMBER: 79-929

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
FADD (phospho Ser191) antibody was raised against a peptide sequence around phosphorylation site of Serine191 (R-S-G (p)-A-M) derived from Human FADD.
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Specificity:
The antibody detects endogenous levels of FADD only when phosphorylated at serine 191.
Predicted Molecular Weight:
25 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
FADD
Additional Names:
MORT1 , FAS-associating death domain-containing protein, Mediator of receptor induced toxicity
Protein Accession Number:
NP_003815.1
Protein Gi Number:
6753812
Ncbi Gene Id Number:
14082
Background:
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Background Reference 1:
Sugano S., Nat. Genet. 36:40-45(2004).
Background Reference 2:
Farmer A., Submitted (MAY-2003).
Background Reference 3:
Venter J.C., Submitted (JUL-2005).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-929

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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