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Western blot analysis of lysed extracts from HT29 and HeLa cells using FAK (Ab-576/577).
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using FAK (Ab-576/577).
Western blot analysis of lysed extracts from HT29 and HeLa cells using FAK (Ab-576/577).

FAK (Ab 576 / 577) Antibody

CATALOG NUMBER: 79-433

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
FAK (Ab-576/577) antibody was raised against a peptide sequence around aa.574~578/575~579 (T-Y-Y-K-A) derived from Human FAK.
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Application Note:
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Specificity:
This antibody detects endogenous level of total FAK protein.
Predicted Molecular Weight:
125 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
PTK2
Additional Names:
FAK, FADK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, JTK2, TKF, FADK 1, PTK2
Protein Accession Number:
NP_005598.3
Protein Gi Number:
27886593
Ncbi Gene Id Number:
5747
Background:
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Background Reference 1:
Parsons, J. T. et al. (2000) Oncogene 19, 5606-5613. Schaller, M. D. et al. (1994) Mol. Cell. Biol. 14, 1680-1688. Chen, H. C. et al. (1996) J. Biol. Chem. 271, 26329-26334. Calalb, M. B. et al. (1995) Mol. Cell. Biol. 15, 954-963.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-433

List Size:
0.1 mg

List Price:

$370.00

Datasheet
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